The Science

The science of 1,5-anhydro-D-glucitol and diabetes

The oral intake of 1,5-AG is between 5 and 10 mg per day although small amounts are produced endogenously.
Non-diabetic individuals and diabetic patients with proper dietary control maintain a constant serum level of 1, 5- AG between 500 and 1000 µg/ml. Approximately 5 to 10 mg are excreted daily from the kidney’s glomeruli and then a portion is reabsorbed through the proximal renal tubules to maintain the normal serum level.
In diabetic patients when serum glucose rises above the renal threshold (usually >180 mg/dL) glucose competitively inhibits the reabsorption of 1,5-AG. Therefore, blood levels of 1,5-AG decrease proportionally to rising blood glucose levels.
Serum 1,5-AG levels fall rapidly when blood glucose climbs over the renal threshold.
When normoglycemia is restored 1,5-anhydroglucitol will recover at a predictable rate of 0.3 µg/ml/day. The time required for recovery depends upon the magnitude and duration of the glycemic episode.

Due to its ability to detect post-prandial hyperglycemia GlycoMark has already proven valuable in monitoring new therapies for post-prandial glucose
GlycoMark levels moved significantly following treatment of diabetic patients with sitagliptin phosphate, exenatide (abstract) or pramlintide.
Both HbA1c and FA showed only slight or no movement post therapy.