Frequently Asked Questions

What are the assay limitations?
The GlycoMark evaluation studies by Nowatzke W. et al. indicate that there is very little interference from triglyceride, hemoglobin or bilirubin (<10% to concentrations of 12.6 mmol/l, 12.1 ug/ml and 911.4 ug/ml, respectively. The GlycoMark manufacturer’s data agrees with these results. They note that GlycoMark is unaffected by glucose to 1,000 mg/dL, maltose to 500 mg/dL, ascorbic acid to 25 mg/dL, uric acid to 20 mg/dL, creatinine to 10 mg/dL and urea to 20mg/dL.

What physical conditions and therapeutics adversely affect GlycoMark?
GlycoMark values may be lowered by persistent glucosurea or by oxyhyperglycemia after gastrectomy. 1,5-AG is also lowered by pregnancy, renal failure (creatinine over 3 g/dL), dialysis, cirrhosis, in patients unable to orally ingest food and those with abnormal glomerular filtration.

Some drugs, such as Polygala, Tenuifolia and Senega syrup and intravenous hyperalimentation may increase 1,5-AG. Anti-hyperglycemic drug therapy increases GlycoMark values; whereas steroids may decrease 1,5-AG.

How stable is the GlycoMark reagent kit, controls and standard?
The GlycoMark reagent, control and standard kits are stable when refrigerated (2-8oC) until the expiration date printed on the box. Reagents and standard are stable for twelve months and the controls are stable for eighteen months from the date of manufacture.

What is the history of 1,5-anhydroglucitol and diabetes?
A history of 1,5 anhydroglucitol, diabetes and GlycoMark is available in the Technical Section of this website. <link to “GlycoMark history” in Overview section.>

What yield can I expect from the GlycoMark kit?
Laboratories report yields between 125 and 135 tests per kit depending upon their instrument and the number of control sets and 50 ug/ml standards they include in each run. When applied to batch runs with 125 samples the controls and standard can be maximized and their contribution to cost per test is minimal.

How can I order GlycoMark reagents, controls and standard?
Call 212-355-2692, fax 212-355-8165 or email ying_hsu@glycomark.com.

How can I get technical support?
Please call 336-725-8181 for assistance with the GlycoMark assay, including setting it up on your instrument.